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KMID : 0358320080490080709
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Korean Journal of Urology
2008 Volume.49 No. 8 p.709 ~ p.714
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Clinical Significance of the Expression of Tubulin α and βII in Prostate Cancer
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Kim Tae-Heung
Kim Tae-Hyoung
Lee Shin-Young
Kim Young-Sun
Kim Mi-Kyung
Myung Soon-Chul
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Abstract
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Purpose: This study examined the significance of tubulin ? and ?Ⅱexpression in benign prostatic hyperplasia(BPH) and prostate cancer. Materials and
Methods: A total 103 cases diagnosed with either BPH or prostate cancer were divided into 4 groups: BPH(n=25), localized prostate cancer(n=41), locally advanced prostate cancer(n=18), metastatic prostate cancer(n=18). The tissues were taken through a transurethral resection of the prostate, suprapubic prostatectomy, prostatic needle biopsy or radical retropubic prostatectomy. The expression was measured by immunohistochemical staining. The degree of expression was graded on a 4-point scale. The data was compared in terms of stage, the serum prostatic specific antigen(PSA) level and Gleason score. The statistical comparisons were made using one-way ANOVA test and a Fisher’s exact test.
Results: The levels of tubulin ? and ?II expression were stronger in the patients with prostate cancer than those with BPH(p＜0.001). On the other hand, there was no difference between metastatic prostate cancer and localized prostate cancer(p＞0.05). The level of tubulin ? expression was stronger in the patients with a Gleason score ≥8 than in those of Gleason score ≤7(p＜0.05), but there was no such difference in tubulin ?II expression. The level of tubulin ? and ?II expression was stronger in the patients with a serum PSA level ≥4ng/ml than in those with the serum PSA level ＜4ng/ml(p＜0.001).
Conclusions: The expression of tubulin ? and ?II may be associated with the development of prostate cancer. These might be used as useful markers for the diagnosis, prognosis and treatment response. (Korean J Urol 2008; 49:709-714)
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KEYWORD
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Tubulin, Prostate, Neoplasms
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